Durrett and Schmidt studies

In 2007  Durrett and Schmidt estimated that for a single mutation to occur in a nucleotide binding site and be fixed in a primate lineage it would take 6 million years alas 6 million years is the timescale alloted by the standard evolutionary model for the transition from our last supposed common ancester with chimps to present day man.

 

Waiting for regulatory sequences to appear
Richard Durrett and Deena Schmidt…

http://projecteuclid.org/DPubS?service=UI&version=1.0&verb=Display&handle=euclid.aoap/1171377175

 Waiting for two mutations: with applications to regulatory sequence evolution and the limits of Darwinian evolution…
http://www.ncbi.nlm.nih.gov/pubmed/18791261

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